PRECLINICAL EVIDENCE FOR EMPLOYING MEK INHIBITION IN NRAS MUTATED PEDIATRIC GASTROENTEROPANCREATIC NEUROENDOCRINE-LIKE TUMORS

Preclinical evidence for employing MEK inhibition in NRAS mutated pediatric gastroenteropancreatic neuroendocrine-like tumors

Background: Pediatric gastroenteropancreatic neuroendocrine tumors are exceedingly rare, resulting in most pediatric treatment recommendations being based on data derived from adults.Trametinib is a kinase inhibitor that targets MEK1/2 and has been employed in the treatment of cancers harboring mutations in the Ras pathway.Methods: We utilized an e

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Equitable stormwater utility fees: an integrated analysis of environmental, socioeconomic and infrastructure factors at the community scale

Municipalities worldwide implement stormwater management programs to mitigate the hydrological and water quality impacts of stormwater runoff.Stormwater utility fees Room Freshner (SWUF) are often used to fund such important programs by collecting revenue from residential and commercial properties.However, existing SWUFs often solely rely on the es

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Assessment of heterotic potential of indica rice hybrids derived from KMR 3/O. rufipogon introgression lines as restorers

Present investigation was carried out to assess the heterotic yield potential of 162 indica rice hybrids derived from twenty six KMR3/O.rufipogon introgression lines (ILs) and six cytoplasmic male sterile (CMS) lines.The derived hybrids and testers were phenotyped for days to 50% flowering, plant height, number of productive tillers and yield per p

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Quiver algebras and their representations for arbitrary quivers

Abstract The quiver Yangians were originally defined for the quiver and superpotential from string Tridonic EM T5 Basic theory on general toric Calabi-Yau threefolds, and serve as BPS algebras of these systems.Their characters reproduce the unrefined BPS indices, which are related to classical Donaldson-Thomas (DT) invariants.We generalize this con

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